Oral Administration of MB-102 Versus Dual Sugar Testing for Gut Permeability

Inclusion criteria for all participants: * Age \> 18 years - male or non-pregnant or lactating females * Participants willing to comply with study requirements * Participants who have signed an informed consent form * Normal or non-clinically significant screening and baseline 12 lead electrocardiogram (ECG) in the opinion of the principal investigator (PI) * Estimated glomerulofiltration rate (eGFR) \> 75 mL/min/1.73 m\^2 * Agreement to not utilize nonsteroidal anti-inflammatory drugs (NSAIDs) until study completion. Inclusion criteria for participants with Crohn's disease: * Participants with active small bowel Crohn's disease diagnosed by an abnormal Magnetic Resonance Enterography (MRE) within 1 month prior to screening * Active Crohn's disease must be characterized by mucosal hyperemia, and/or bowel wall thickening and/or vascular engorgement Exclusion criteria for all participants: * Women who are pregnant, lactating, or planning to become pregnant during the study, or women who are of childbearing potential unwilling to use an adequate method of birth control a. Males must be willing to practice abstinence or utilize adequate contraception from dosing day to at least 7 days post dose * Participation in another interventional trial within 30 days of dosing or concurrently enrolled in any other medical research study which could impact the results of the study * Unable to tolerate an overnight fast * NSAID use within 14 days of Day 1 * History of drug or alcohol abuse within the past year * Diagnosis of ulcerative colitis, indeterminate colitis, pseudomembranous colitis, or celiac disease * Prior or current diagnosis of an autoimmune disease * Gastrointestinal surgery (including appendectomy) within 12 weeks prior to screening or has surgery planned or deemed likely to require surgery during the study * Type 1 or 2 diabetes * History of severe allergic hypersensitivity reactions (unacceptable adverse events) or anaphylactoid reaction to any allergen including drugs, or MB-102 (intolerance to a drug is not considered a drug allergy) * Known history of testing positive for acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV) * Site personnel immediately associated with the study or their immediate family members * Any characteristics which, in the opinion of the investigator, makes the participant a poor candidate for participation in the clinical trial * Prior exposure to MB-102 * Any changes to chronic medication therapy or initiation of new medications between Testing Day 1 and Testing Day 2 * Current urinary tract infection * Body mass index \> 30 kg/m\^2 * Prior history of small bowel malignancy or resection surgery * Unable to meet the requirements of the study including 12+ hour study visits Additional exclusion criteria for normal participants: * Fecal transplant within 1 year * Prior or current graft-vs.-host disease * Prior or current history of diverticulitis * Current or prior history of fatty liver * Current use of any biologic therapy or current use of the following medications: sulfasalazine, mesalamine, olsalazine, balsalazide, prednisone, cyclosporine, azathioprine, 6-mercaptopurine, tacrolimus, methotrexate, intravenous immunoglobulin, anti-diarrheal agents * Prior antibiotic therapy within 30 days of screening * Undiagnosed chronic gastrointestinal upset or food intolerance history * Recent history of significant unplanned weight loss, blood in the stool or acute episodes of diarrhea * First-degree relative (sibling, parent, child) has inflammatory bowel disease (Crohn's disease, ulcerative colitis, proctitis, indeterminate colitis) * History of Crohn's disease Additional exclusion criterion for participants with Crohn's disease: \- Participant on Total Parenteral Nutrition (TPN)