BMAC Nerve Allograft Study

Inclusion Criteria: * Male or non-pregnant female 18 to 74 years of age. * Undergoing peripheral nerve exploration or grafting with allograft in the upper extremity. * Subjects must be inpatients or scheduled for surgery at the time of study enrollment. * Has nerve conduction block injuries to the ulnar, median, radial or musculocutaneous nerve of either upper extremities that is less than two years from injury. * Be willing to undergo tension free end-to-end nerve graft coaptation on both the proximal and distal portion of the nerve gap with the Avance Nerve Graft. * Be willing to have bone marrow harvested from own body, concentrated, and applied to the site of nerve injury following the insertion of the Avance Nerve Graft. * Be willing to participate and able to comply with all aspects of the treatment and evaluation schedule over a 18-month duration. * Capable of giving their own consent to participate in the study, and willing to sign and date an IRB-approved written informed consent prior to initiation of any study procedures. * Nerve conduction injury affecting sensory and motor function or solely motor function in the upper extremity. * Nerve gaps following resection, up to 7 cm, inclusive. Exclusion Criteria: * Subjects with Type 1 Diabetes Mellitus or Type 2 Diabetes Mellitus requiring regular insulin therapy. * Subjects who are undergoing or expected to undergo treatment with chemotherapy, radiation therapy, or other known treatment which affects the growth of neural and/or vascular system. * History of neurodegenerative disease, neuropathy, or diabetic neuropathy. * History of chronic ischemic condition of the upper extremity. * Cognitive limitation or mental illness preventing informed consent. * Nerve injuries \>2 years post initial injury. * Any participant who at the discretion of the Investigator is not suitable for inclusion in the study.