Impact of Nicotine on Retinal Vascularization

Fondation Ophtalmologique Adolphe de Rothschild58 enrolled

Overview

The main hypothesis is the nicotine is associated with a modification of retinal micro-vascularization. Patients will be recruited during their ophthalmologic consultation at the Rothschild Foundation, an OCT-A will be realized and data relating to medical history, oral contraceptive intake and nicotine consumption via cigarette or e-cigarette data will be collected. The objective is to seek an association between retinal vascular density and inhaled nicotine intake.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Tabagism

Interventions

OCT-A (Optical Coherence Tomography)DIAGNOSTIC_TEST

Included patients will have an OCT-A and will be questioned about their nicotine intake, their background and taking an oral conception

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria * For group of smokers: Patient reporting active smoking for at least 3 months and at least 1 cigarette per day on average over a week * For group of vapers : Patient using exclusively the electronic cigarette with a nicotine level of more than 6mg/ml for at least 3 months and at least 1 times per day on average over a week. * For group of no-smokers no-vapersNon-smoking and no vaping, for more than 6 months Non-inclusion criteria: * Caffeine intake within 2 hours prior to the OCT-A exam * ametropia greater than + 3 dioptres of hyperopia or-3 dioptres of myopia * astigmatism greater than 2 dioptres * Known retinal or retina vascular pathology

Locations (1)

Fondation A de Rothschild

Paris, France

Outcomes

Primary Outcomes

Density of retinal vascular Plexus (quantitative variable expressed as a percentage) using OCT-A.

Time frame: At the inclusion consultation

Data from ClinicalTrials.gov

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