Description of the evolution of the biological characteristics of immune blood populations and biomarkers of interest in patients who have received allogeneic hematopoietic stem cell transplantation.
a more in-depth analysis of the different immune cell sub-populations as well as serum markers (cytokines) would provide a better understanding of post-allograft immune reconstitution mechanisms and identify potential immunologic biomarkers predictive of GVH or relapse.
Study Type
OBSERVATIONAL
Enrollment
1,020
Some sampling times will be systematic, while others will only be performed in the presence of specific post-transplant clinical events (eg relapse, GVH ...).
In the case of a transplant from an intrafamily donor (genoid or haploid), we will also collect blood samples from the donor. A single blood sample of 28 mL (7 EDTA tubes) will be made. In order not to represent an additional sample for the donor, this sample will be taken before the mobilization of the hematopoietic stem cells, during the biological assessment required for the biological donation qualification.
Institut Paoli-Calmettes
Marseille, Bouches-du Rhône, France
Evolution of the immune blood populations in patients who have received allogeneic hematopoietic stem cell transplantation.
longitudinal study of the immune subpopulations of allografted patients for hematological malignancies.
Time frame: 5 years after HSC transplantation
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