Efficacy and Safety of Ixazomib and Dexamethasone Refractory Autoimmune Cytopenia

Inclusion Criteria: ITP patients: 1. Age \>= 18 years 2. Diagnosis of ITP according to the international definition (Rodeghiero et al Blood 2009) 3. Platelets count \< 30 x 109/L or \<50 x 109/L if presence of hemorrhagic events or other reason left up to investigator discretion within the months preceding inclusion. 4. Multirefractory ITP defined as patients who have previously failed to maintain a response after rituximab (anti-CD20), splenectomy, and romiplostim and eltrombopag, except if patients have any contraindications or refused these treatments wAIHA patients 1. Age \>= 18 years 2. Diagnosis of wAIHA , symptomatic anemia and a positive direct antiglobulin test 3. Refractory AIHA who have previously failed to maintain a sustained response after rituximab (anti-CD20) and splenectomy except if patients have any contraindications or refused these treatments. For all patients; 1. Absolute neutrophil count (ANC) \>=1,000/mm3 2. Gammablobulin level \> 7 g/l 3. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =\< 3x ULN. 4. Calculated creatinine clearance \>=30 mL/min 5. Voluntary written consent must be given before performance of any study related procedure not part of standard medical care, with the understanding that consent may be withdrawn by the patient at any time without prejudice to future medical care. Exclusion criteria 1. Major surgery within 14 days before enrollment. 2. Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment. 3. Female patients who are lactating or have a positive serum pregnancy test during the screening period. 4. Evidence of current uncontrolled cardiovascular conditions, including uncontrolled hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart failure, unstable angina, or myocardial infarction within the past 6 months. 5. Systemic treatment, within 14 days before the first dose of ixazomib, with strong CYP3A inducers (rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital, azathioprine), or use of St. John's wort. 6. ) Positive HIV test and/or hepatitis virus C infection and/or positive hepatitis B virus surface antigen or core antibody (HbsAg or HBcAb) and/or Active Varicella or Herpes and zoster infection. 7. Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol. 8. Known allergy to any of the study medications, their analogues, or excipients in the various formulations of any agent. 9. Known GI disease or GI procedure that could interfere with the oral absorption or tolerance of ixazomib including difficulty swallowing. 10. Diagnosed or treated for another malignancy within 2 years before study enrollment or previously diagnosed with another malignancy and have any evidence of residual disease. Patients with nonmelanoma skin cancer or carcinoma in situ of any type are not excluded if they have undergone complete resection. 11. Unable to comply with study and follow-up procedures due to psychiatric disorders or any other reason. 12. Inflammatory central nervous system disorder. 13. Patient has \>=Grade 3 peripheral neuropathy, or Grade 2 with pain on clinical examination during the screening period. 14. Participation in other clinical trials, including those with other investigational agents not included in this trial, within 30 days of the start of this trial and throughout the duration of this trial. 15. Patients that have previously been treated with ixazomib, or participated in a study with ixazomib whether treated with ixazomib or not. 16. Total bilirubin ≥ 1.5 x the upper limit of the normal range (ULN).