The purpose of this study is to compare the efficacy of different amoxicilline treatment regimens in patients with erythema migrans.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
510
Patients will receive amoxicillin 500 milligram tid for 10 days
Patients will receive amoxicillin 500 milligram tid for 14 days
Patients will receive amoxicillin 500 milligram bid for 14 days
University Medical Centre Ljubljana
Ljubljana, Slovenia
RECRUITINGUniversity Medical Centre Ljubljana
Ljubljana, Slovenia
NOT_YET_RECRUITINGNumber (frequency) of patients with objective manifestations of Lyme borreliosis or subjective Lyme borreliosis-associated/post-Lyme borreliosis symptoms
At each visit physical examination wil be performed and clinical signs indicating objective manifestations of Lyme borreliosis, such as erythema migrans, will be searched for and documented. At each visit patients will be asked an open question about any health-related symptoms that had newly developed or worsened since the onset of erythema migrans. If these symptoms will have no other known medical explanation, they will be regarded as Lyme borreliosis-associated constitutional symptoms at enrolment or post-Lyme borreliosis symptoms at follow-up.
Time frame: One year follow-up
Number (frequency) of patients with nonspecific symptoms
At each visit patients will be asked to complete a written questionnaire asking whether they had had any of eight non-specific symptoms (fatigue, arthralgias, headache,myalgias, paraesthesias, memory difficulties, concentration difficulties and irritability) within the preceding week.
Time frame: One year follow-up
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No intervention.