In this prospective, controlled trial, patient after TAVI will be randomized to either exercise training or usual care group.
Patients after transcatheter aortic valve replacement (TAVI) are particularly old and severely deconditioned and are thus likely to benefit from cardiac rehabilitation programs. In this controlled trial, patients after TAVI will be randomized to either exercise training or usual care. The aim of our study is to compare the effect of exercise training vs. usual care on: 1. exercise capacity 2. vascular function 3. parameters of heart failure, inflammation and homeostasis 4. arrhythmogenic potential 5. health-related quality of life
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Continuous exercise training 2 times per week for a period of 12 weeks.
UMC Ljubljana
Ljubljana, Slovenia
Change of maximal oxygen uptake during exercise
ml/kg/min
Time frame: 3 months
Change of flow-mediated dilatation (FMD) of the brachial artery
% flow-mediated dilatation and arterial stiffness
Time frame: 3 months
Change of arterial stiffness coefficient
coefficient
Time frame: 3 months
Change of value of blood N terminal-proBNP
ng/l
Time frame: 3 months
Change of value of blood D-dimer
microg/l
Time frame: 3 months
Change of value from-the-questionnaire-obtained quality of life
points
Time frame: 3 months
Change of ECG waves
Estimated with digital high-resolution ECG
Time frame: 3 months
Change in the result of the 6-minute walking test
metres
Time frame: 3 months
Change og the heart rate variability
Estimated with digital high-resolution ECG
Time frame: 3 months
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