Subconjunctival Injection of Allogeneic Mesenchymal Stem Cells in Severe Ocular Chemical Burn

Fondation Ophtalmologique Adolphe de Rothschild7 enrolled

Overview

The objective of this pre-clinical study is to demonstrate the robustness of Bone Marrow derived Mesenchymal Stem Cells (BM-MSC) production, to treat patients with severe eye burns. For bone marrow donors who agree to participate, a 10 ml BM sample will be collected apart the 1 liter BM dedicated to transplantation. A maximum of three donors of allogeneic BM-MSCs will be included. A ready-to-use BM-MSC suspension will be produced and stored for 10 years to accumulate data about stability of cryopreserved cells.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Bone Marrow Donor

Interventions

bone marrow harvestOTHER

During bone marrow harvest, an additional 10 mL sample will be collected for the study.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: \- Patient with a bone marrow donation planned Exclusion criteria: * The donor is finally not eligible * The harvest cannot be performed * The sample cannot be obtained during the BM harvest procedure

Locations (1)

Saint Louis Hospital, APHP

Paris, France

Outcomes

Primary Outcomes

The number of donors needed to obtain 3 BM harvest.

Time frame: 6 months

Data from ClinicalTrials.gov

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