The investigators planned to research the association between plasma melatonin and coronary artery calcification in a Chinese population.
Coronary artery calcification (CAC) is prevalent in coronary artery disease (CHD), and the extent of CAC predicts cardiovascular risk. The causes of CAC include dysregulated matrix metabolism, epitaxial mineral deposition, inflammation, oxidative stress, and apoptosis. Melatonin is the main indoleamine produced by the pineal gland; it is known recently to have anti-inflammatory, anti-cancer and antioxidant activities. Several studies have shown that melatonin protects against inflammation and apoptosis in vascular calcification. Melatonin also inhibits oxidative stress-induced apoptosis and calcification in endplate chondrocytes. However, no study has evaluated whether melatonin is associated with CAC in patients with coronary atherosclerosis. The investigators planned to research the association between plasma melatonin and coronary artery calcification.
Study Type
OBSERVATIONAL
Enrollment
574
PLA general hospital
Beijing, China
correlations of CAC score with melatonin concentrations
CAC score was obtained using the coronary CTA and Agatston score.
Time frame: Subjects underwent a CAC scan at baseline.
correlations of CAC score with high-sensitivity C-reactive protein (hsCRP) level
The hsCRP levels were analyzed by a sandwich enzyme linked immunosorbent assay.
Time frame: Subjects had blood samples collected at baseline.
correlations of CAC score with malondialdehyde (MDA) level
The MDA levels were analyzed by a sandwich enzyme linked immunosorbent assay.
Time frame: Subjects had blood samples collected at baseline.
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