This is prospective cohort study. All the patients with primary cervical cancer in the future three years in Peking Union Medical College Hospital will be included in this study. Before and after the major therapy (including at least radical hysterectomy and/or radiotherapy), the patients accept (1) the questionnaires survey about quality of life; (2) urodynamic testing; (3) rectum dynamics testing and (4) ovarian reserve function. The survival outcomes (disease-free survival and overall survival) will be supplemented as secondary objectives.
Study Type
OBSERVATIONAL
Enrollment
10,000
Including four kinds of questionnaires: European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 (V3); EORTC QLQ-CX24; Eligibility Criteria (FSFI); and Short forms of two condition-specific quality-of-life questionnaires for women with pelvic floor disorders (PFIQ-7)
Urodynamic testing consists of important urodynamic parameters including: Bladder capacity at the first void sense Bladder capacity at normal desire to void Bladder capacity at strong desire to void Qmax Qave Pves at Qmax Pdet at Qmax Cves at SDV Cdet at SDV Residual urine volume
Rectum dynamics testing consists of important parameters of rectum activities
Testing for ovarian reserve function consists of: Follicle-stimulating hormone Estradiol Anti-mullerian hormone Inhibin B
Lei Li
Beijing, Beijing Municipality, China
RECRUITINGScores from EORTC QLQ-C30
Scores calculated from European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30
Time frame: Change from the baseline of four weeks before major therapy at following-up. The standard scores ranges from 0 to 100, and the higher score, the more inferior quality of life.
Scores from EORTC QLQ-CX24
Scores calculated from EORTC QLQ-CX24
Time frame: Change from the baseline of four weeks before major therapy at following-up. The standard scores ranges from 0 to 100, and the higher score, the more inferior quality of life.
Concentration of follicle-stimulating hormone
Follicle-stimulating hormone tested in peripheral blood
Time frame: Change from the baseline of four weeks before major therapy at following-up
Concentration of estradiol
Estradiol tested in peripheral blood
Time frame: Change from the baseline of four weeks before major therapy at following-up
Concentration of anti-mullerian hormone
Anti-mullerian hormone tested in peripheral blood
Time frame: Change from the baseline of four weeks before major therapy at following-up
Concentration of inhibin B
Inhibin B tested in peripheral blood
Time frame: Change from the baseline of four weeks before major therapy at following-up
Bladder capacity at the first void sense
Bladder capacity at the first void sense tested by urodynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
Bladder capacity at normal desire to void
Bladder capacity at normal desire to void tested by urodynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
Bladder capacity at strong desire to void
Bladder capacity at strong desire to void tested by urodynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
Maximun flow rate
Maximun flow rate tested by urodynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
Average flow rate
Average flow rate tested by urodynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
Bladder pressure at maximun flow rate
Bladder pressure at maximun flow rate tested by urodynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
Detrusor pressure at maximun flow rate
Detrusor pressure at maximun flow rate tested by urodynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
Bladder compliance at strong desire to void
Bladder compliance at strong desire to void tested by urodynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
Detrusor compliance at strong desire to void
Detrusor compliance at strong desire to void tested by urodynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
Residual urine volume
Residual urine volume tested by urodynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
Anal sphincter pressure
Anal sphincter pressure tested by rectum dynamic testing
Time frame: Change from the baseline of four weeks before major therapy at following-up
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.