This study will compare meniscal healing of non-vascularised area augmented or not by bone marrow injected under a protective collagen membrane (meniscal wrapping)
Historically, meniscus was considered as none essential for knee joint, and its removal by meniscectomy was the first-line treatment. Many studies have shown a negative progress towards osteoarthritis after meniscus ablation. This approach has gradually changed to preserve this meniscal capital, making way for new treatments as sutures. However the vascular organization of the meniscus is crucial for its cure. The healing potential of lesions in the meniscus non-vascularised aera is considered insufficient, and are often treated by a partial meniscectomy, resulting in a high risk of osteoarthritis. It appears therefore necessary to develop new strategies, as meniscal wrapping, to preserve meniscus presenting this type of damage.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
128
meniscal tear sutured + bone marrow injection/collagen membrane
meniscal tear sutured
Centre Hospitalier Universitaire Vaudois - CHUV
Lausanne, Canton of Vaud, Switzerland
RECRUITINGDr Robin MARTIN
Lausanne, Canton of Vaud, Switzerland
RECRUITINGChange in integrity and healing of meniscus repair
Arthrography (arthro-CT)
Time frame: 12 and 24 months after treatment
Knee injury and Osteoarthritis Outcome Score (KOOS)
Changes in the 5 subscales of KOOS as assessed from baseline to 24 months post-surgery
Time frame: baseline and 3, 12 and 24 months after treatment
International Knee Documentation Committee Score (IKDC)
Change in physical pain and function as assessed by IKDC score from baseline to 24 months post-surgery
Time frame: baseline and 3, 12 and 24 months after treatment
SF-12 Survey
Change in functional health and well-being as assessed by SF-12 Survey from baseline to 24 months post-surgery
Time frame: baseline and 3, 12 and 24 months after treatment
Failure rate
Number of readmission for meniscus tear
Time frame: up to 24 months
Change in integrity of meniscus and adjacent tissues (cartilage, bone, synovial tissue)
Imaging: MRI
Time frame: 12 months after treatment
Rate of suture type-associated complications
Post-operative data collection: inflammation, pain, recurrent tear of the meniscus, instability or stiffness joint, perimeniscal cyst formation, hemarthrosis or effusion.
Time frame: up to 24 months
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