Platelets are important mediators of an inflammatory response and a key component of the innate immune system to defend the human body against invading pathogens. However, little evidence exists regarding the number of platelets that should be used als transfusion threshold in septic patients. In this trial platelet transfusion will be performed with either \<50000/µl or \<20000/µl as a trigger.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Transfusion of platelets
Overall survival in 90 day follow-up period
overall survival at 90 days
Time frame: 90 days
all cause mortality at 6 months
overall survival at 6 months
Time frame: 6 months
resolution of shock
time to normalization of lactate levels and end of vasopressor therapy
Time frame: 5 days
ICU length of stay
length of stay on ICU ward
Time frame: 28 days
duration of mechanical ventilation support
time to extubation
Time frame: 28 days
renal replacement therapy
frequency and duration of renal replacement therapy
Time frame: 28 days
bleeding events
bleeding events requiring transfusion during ICU stay
Time frame: 28 days
SOFA score
Sepsis-related organ failure assessment score
Time frame: 28 days
discharge location
discharge to home, ward, rehabilitation unit, nursing home
Time frame: 90 days
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