In order to determine if Intralipid 20% can be used to reverse the effects of local anesthetics, the investigators will recruit 18 volunteers who will be asked to come to HSS for two study visits. Small amounts of local anesthetics will be injected into the volunteers' thighs during both visits. During one visit volunteers will receive Intralipid 20% and during the other visit they will receive a saline solution. The study team will measure how quickly normal sensation returns to the thighs when the volunteers get Intralipid 20% compared to saline.
The purpose of this study is to determine if a fat solution (Intralipid 20%) given intravenously can reverse the effects of local anesthetics. Local anesthetics are drugs that cause numbness when they are injected into different parts of the body. Local anesthetics are important drugs because they allow doctors to perform surgeries and other procedures on patients; however, there are certain instances where it would be helpful to reverse the effects of local anesthetics and reduce the amount of time that they produce numbness. In order to determine if Intralipid 20% can be used to reverse the effects of local anesthetics, the investigators will recruit 18 volunteers who will be asked to come to HSS for two study visits. Small amounts of local anesthetics will be injected into the volunteers' thighs during both visits. During one visit volunteers will receive Intralipid 20% and during the other visit they will receive a saline solution. The study team will measure how quickly normal sensation returns to the thighs when the volunteers get Intralipid 20% compared to saline.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
18
3 mL of test solution to a skin area on the thigh, 2cm in diameter
3 mL of test solution to a skin area on the thigh, 2cm in diameter
3 mL of test solution to a skin area on the thigh, 2cm in diameter
Hospital of Special Surgery
New York, New York, United States
Time to complete normal sensation after lidocaine 1%
The time (measured in minutes) when the participant reports normal sensation of both cold swab and pinprick at the injection site of lidocaine 1%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
Time to complete normal sensation after lidocaine 2%
The time (measured in minutes) when the participant reports normal sensation of both cold swab and pinprick at the injection site of lidocaine 2%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
Time to complete normal sensation after Bupivacaine 0.5%
The time (measured in minutes) when the participant reports normal sensation of both cold swab and pinprick at the injection site of Bupivacaine 0.5%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
Time to complete normal sensation after Bupivacaine 0.25%
The time (measured in minutes) when the participant reports normal sensation of both cold swab and pinprick at the injection site of Bupivacaine 0.25%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
Time to normal cold swab sensation after lidocaine 1%
The time (measured in minutes) when the participant reports normal sensation of cold swab at the injection site of lidocaine 1%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
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3 mL of test solution to a skin area on the thigh, 2cm in diameter
a 250ml bag administered intravenously
a 250ml bag administered intravenously
3 mL of test solution to a skin area on the thigh, 2cm in diameter
Time to normal pinprick sensation after lidocaine 1%
The time (measured in minutes) when the participant reports normal sensation of pinprick at the injection site of lidocaine 1%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
Time to normal cold swab sensation after lidocaine 2%
The time (measured in minutes) when the participant reports normal sensation of cold swab at the injection site of lidocaine 2%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
Time to normal pin prick sensation after lidocaine 2%
The time (measured in minutes) when the participant reports normal sensation of pinprick at the injection site of lidocaine 2%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
Time to normal pinprick sensation after Bupivacaine 0.5%
The time (measured in minutes) when the participant reports normal sensation of pinprick at the injection site of Bupivacaine 0.5%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
Time to normal cold swab sensation after Bupivacaine 0.5%
The time (measured in minutes) when the participant reports normal sensation of cold swab at the injection site of Bupivacaine 0.5%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
Time to normal cold swab sensation after Bupivacaine 0.25%
The time (measured in minutes) when the participant reports normal sensation of cold swab at the injection site of Bupivacaine 0.25%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours
Time to normal pinprick sensation after Bupivacaine 0.25%
The time (measured in minutes) when the participant reports normal sensation of pinprick at the injection site of Bupivacaine 0.25%. Although measured for each individual participant, the average time across all participants is reported.
Time frame: up to 24 hours