Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal

Sub-Study 1 Inclusion Criteria: 1. 18 years or older 2. Able to read and speak English 3. Non-Hispanic African American (Black) or non-Hispanic white race 4. Daily smoker (5 or more cigarettes a day for the past one year and having smoked more than 100 cigarettes in lifetime) or non-smoker (smoked fewer than 100 cigarettes in a lifetime and no smoking-not even a puff- in the last year) 5. Currently residing in Alabama Exclusion Criteria: 6. Non-English speaking 7. Lives in restricted environment that does not allow smoking 8. Pregnant or lactating 9. Daily or exclusive use of other tobacco products (e.g., cigars, e-cigarettes) if a smoker; if non-smoker, any other tobacco product use is exclusionary 10. Currently receiving smoking cessation treatment or using electronic cigarettes or other tobacco to try and quit smoking cigarettes 11. Participants would work outside normal 7 a.m. to 6 p.m. hours 12. Former smokers Sub-study 2 Inclusion Criteria: 1. 18 years or older 2. Able to read and speak English 3. Non-Hispanic African American (Black) or non-Hispanic white race 4. Daily smoker defined as smoking 5 or more cigarettes a day for the past one year and having smoked more than 100 cigarettes in lifetime, as well as by an expired Carbon Monoxide (CO )cut-off of Carbon Monoxide (CO)\>10ppm and positive cotinine test to ensure daily smoking OR non-smoker defined as smoking fewer than 100 cigarettes in a lifetime and no smoking-not even a puff- in the last year, as well as by an expired Carbon monoxide (CO) cut-off of Carbon Monoxide (CO)\<3 ppm and negative cotinine test. 5. Currently residing in Alabama Exclusion Criteria: 6. Non-English speaking 7. Lives in restricted environment that does not allow smoking 8. Pregnant or lactating 9. Testing positive on urine drug screen test at baseline - any drugs other than Tetrahydrocannabinol (THC) not allowed 10. Daily or exclusive use of other tobacco products (e.g., cigars, e-cigarettes) if a smoker; if non-smoker, any other tobacco product use is exclusionary 11. Currently receiving smoking cessation treatment or using electronic cigarettes or other tobacco to try and quit smoking cigarettes 12. Participants would work outside normal 7 a.m. to 6 p.m. hours 13. Former smokers 14. History of a medical condition (e.g., bipolar disorder, migraine, or seizure disorder) that might be exacerbated by sleep deprivation as a result of Study 3 15. History of a serious lung/breathing disease that prevents one from walking or holding their breath for 10 seconds (in order to complete Carbon Monoxide breath test) 16. Cognitive impairment such that participant is unable to provide informed consent 17. Acutely suicidal, manic, acutely intoxicated, or otherwise not stable enough to provide informed consent 18. Living outside of the Birmingham metro area (\> 20 miles away from University of Alabama at Birmingham Main Campus) Sub-study 3 Inclusion Criteria: 1. 18 years or older 2. Able to read and speak English 3. Non-Hispanic African American (Black) or non-Hispanic white race 4. Daily smoker defined as smoking 5 or more cigarettes a day for the past one year and having smoked more than 100 cigarettes in lifetime, as well as by an expired Carbon Monoxide (CO) cut-off of Carbon Monoxide (CO)\>10ppm and positive cotinine test to ensure daily smoking 5. Currently residing in Alabama Exclusion Criteria: 6. Non-English speaking 7. Lives in restricted environment that does not allow smoking 8. Pregnant or lactating 9. Daily or exclusive use of other tobacco products (e.g., cigars, e-cigarettes) if a smoker; if non-smoker, any other tobacco product use is exclusionary 10. Currently receiving smoking cessation treatment or using electronic cigarettes or other tobacco to try and quit smoking cigarettes 11. Participants would work outside normal 7 a.m. to 6 p.m. hours 12. Former smokers 13. History of a medical condition (e.g., bipolar disorder, migraine, or seizure disorder) that might be exacerbated by sleep deprivation as a result of Study 3 14. Currently taking any psychiatric medications, pain medications (i.e., opioids), or sleep medications (e.g., Ambien, trazodone, melatonin pills, Cannabidiol (CBD) products) 15. History of a serious lung/breathing disease that prevents one from walking or holding their breath for 10 seconds 16. Testing positive on urine drug screen test at baseline - any drugs other than Tetrahydrocannabinol (THC) not allowed 17. Has an apnea-hypopnea index (AHI) score of \> 15 on home sleep testing that was conducted during sub-study 2 18. Uses Continuous positive airway pressure (CPAP) machine to sleep at night 19. Cognitive impairment such that participant is unable to provide informed consent 20. Acutely suicidal, manic, acutely intoxicated, or otherwise not stable enough to provide informed consent 21. Living outside of the Birmingham metro area (\> 20 miles away from University of Alabama at Birmingham Main Campus)