Citrate Anticoagulation for Postdilution Hemofiltration

Heinrich-Heine University, Duesseldorf100 enrolled

Overview

This study evaluates a protocol for regional citrate anticoagulation in critically ill patients with acute kidney injury who are treated with continuous veno-venous haemofiltration in postdilution mode.

Acute kidney injury (AKI) requiring continuous renal replacement therapy (CCRT occurs in approx. 15 % of all intensive care patients. A sustained and prolonged filter running time is required to deliver an effective dialysis dose. This requires effective anticoagulation. Today, regional citrate anticoagulation (RCA) is preferred over systemic anticoagulation because of prolonged filter lifetimes and less adverse effects. We here study prospectively patients with AKI who are treated with continuous veno-venous haemofiltration using an RCA protocol. We will evaluate all parameters of CRRT including filter running times, delivered dialysis dose, causes for treatment interruption and control of pH and electrolytes.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Acute Kidney Injury Critical Illness

Interventions

renal replacement therapy as clinically indicatedOTHER

Continuous renal replacement therapy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * acute kidney injury * critical illness and treatment at ICU Exclusion Criteria: * age \< 18 years * pregnancy or breast feeding * severe lactate acidosis ( \> 10 mmol/l) for longer than 6 hours and pH \< 7.2

Locations (1)

Intensivstation ZOM1 Klinik für Anästhesiologie Universitätsklinikum Düsseldorf

Düsseldorf, Germany

RECRUITING

Outcomes

Primary Outcomes

Filter running time

Filterlifetime with regional citrate anticoagulation for haemofiltration

Time frame: 72 hours

Data from ClinicalTrials.gov

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