The object of this study is to investigate the damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex layer (GCL+) in diabetic patients without retinal microangioma as detected by fundus fluorescein angiography (FFA) and to determine the kind of nerve damage more likely to indicate early injury.
Patients with type 2 diabetes mellitus and healthy volunteers will be included in our study. Patients with retinal microangioma are excluded by FFA. The parameters around the optic disc and macular area of the above two groups are measured by optical coherence tomography (OCT), and the results will be analyzed using the SPSS 22.0 software.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
720
Routine ophthalmic examination, including slit lamp, intraocular pressure, and fundus examinations using direct or indirect ophthalmoscopy after pupil dilation and optical coherence tomography (OCT) examination. Patients with DM also underwent fundus fluorescein angiography (FFA) examination.
The third affiliated hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
RECRUITINGPeripapillary RNFL thickness
Peripapillary RNFL thickness
Time frame: 96 weeks
GCL+ in the macular area obtained using the 3D wide mode
GCL+ in the macular area obtained using the 3D wide mode
Time frame: 96 weeks
Retinal thickness in all macular regions
Retinal thickness in all macular regions
Time frame: 96 weeks
RNFL thickness in the macular area obtained using the 3D Macula (v) mode
RNFL thickness in the macular area obtained using the 3D Macula (v) mode
Time frame: 96 weeks
GCL+ thickness in the macular region obtained using the 3D Macula (v) mode
GCL+ thickness in the macular region obtained using the 3D Macula (v) mode
Time frame: 96 weeks
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