Meta-analysis of Stannous Fluoride and the Effects on Gingival Health

Procter and Gamble2,890 enrolled

Overview

The aim of this 18 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices when used up to 3 months on gingivitis relative to a positive or negative control dentifrice.

Study Type

OBSERVATIONAL

Enrollment

2,890

Conditions

Gingivitis

Interventions

Stannous Fluoride DentifriceDRUG

Experimental stannous fluoride (0.454%) dentifrice

Positive control dentifriceDRUG

Positive control dentifrice containing (0.3%) triclosan.

Negative control dentifriceDRUG

Negative control dentifrice containing either sodium fluoride (0.243%) or sodium monofluorophosphate (0.76%)

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Subjects were excluded from this study for the following reasons; * pregnancy, * rampant caries, * severe periodontitis, * at discretionary of the Principal Investigator.

Locations (1)

Multiple P&G Investigation Clinical Sites

Cincinnati, Ohio, United States

Outcomes

Primary Outcomes

Number of Bleeding Sites

Change from baseline as measured on number of bleeding sites (gingival bleeding index or Loe Silness index).

Time frame: Up to 12 Weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.