Peripheral Vascular Disease and Coronary Artery Disease

Harbin Medical University350 enrolled

Overview

This study aims at evaluating the relationship between peripheral artery plaque characteristics evaluated by ultrasound and coronary culprit lesion characteristics evaluated by OCT in ACS patients.

Patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI) and optical coherence tomography (OCT) are included in this study. Two skillful echocardiographers will evaluate peripheral artery plaque characteristics by ultrasound.Ultrasound parameters of peripheral artery will be compared among patients with different coronary culprit lesion characteristics, such as plaque rupture and plaque erosion.

Study Type

OBSERVATIONAL

Enrollment

350

Conditions

Acute Coronary Syndrome

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed as ACS underwent coronary angiography and OCT examination * Agreed to accept peripheral artery ultrasound examination Exclusion Criteria: * In-stent restenosis, coronary dissection, coronary spam, thrombus * left main artery disease * Age\>85 years old * Cardiogenic shock or stroke admission * Severe hepatic or renal dysfunction * Poor quality of OCT image or massive thrombus

Locations (1)

The Second Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China

Outcomes

Primary Outcomes

Differences in ultrasound parameters of peripheral artery plaque according to different coronary culprit lesion morphology.

Plaque rupture is characterized by the presence of fibrous cap discontinuity with a cavity formation. plaque erosion is characterized by the presence of the attached thrombus overlying an intact and visual plaque, luminal surface irregularity at the culprit lesion in the absence of thrombus, or attenuation of the underlying plaque by thrombus without superficial lipid or calcification immediately proximal or distal to the site of thrombus.Patients with plaque erosion have less plaques, lower intima-media thickness (IMT), lower plaque score (PS) compared to patients with plaque rupture.

Time frame: Baseline

Data from ClinicalTrials.gov

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