The main purpose of this study is to investigate the existence of emotional attention impairments in Alzheimer's Disease, in correlation with amygdala and attention networks alterations. To this end, functional and structural neuroimaging will be used. A face expression recognition task, along with eyetracking, will be used to assess emotional attention impairments.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
41
We will present emotional expressions to participants. Their task will be to determine which emotion is expressed by each face. Participants' eye movements and brain activity will be recorded while they explore the face.
Grenoble University Hospital
La Tronche, France
Classic recognition score
Facial expression recognition score (%)
Time frame: 1 hour
Classic fixation time faces
Fixation time on eyes as measured with eyetracking (ms)
Time frame: 1 hour
Fixation time scenes
Fixation time on emotional scenes outside of MRI
Time frame: 30 mn
Classic fMRI activity
fMRI activity in amygdala and emotional attention networks during face exploration and resting-state
Time frame: 2 hours
Alternative recognition score
Facial expression recognition score (%) during an alternative task designed to encourage focus on the eyes
Time frame: 1 hour
Alternative fixation time faces
Fixation time on eyes as measured with eyetracking (ms) during this alternative task.
Time frame: 1 hour
Alternative fMRI activity
fMRI activity in amygdala and emotional attention networks during this alternative task
Time frame: 2 hours
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