Double Blinded, Randomized, Placebo-controlled Clinical Study for Nelumbinis Semen

\<Inclusion Criteria\> * Volunteers were selected based on following meet conditions;Men and women, who have willingness and capacity to comply with the study protocol, are included if they were aged 18 to 65 years. * Volunteers, who can understand Korean and English alphabet are selected. * Volunteers, who can communicate with clinical trial performer fully, comply with the all tests and medical examinations performed by study protocol. * All volunteers or their protectors understand purpose of study fully and sign their names or seal. * Volunteers, who do not come under exclusion criteria are selected. * BDI score of Volunteers, who can be \>= 5. \<Exclusion Criteria\> * Volunteers were excluded if they are applied to following meet conditions; Volunteers with fasting glucose level over 126 mg/dl. * Volunteers with hypertension as having over 140 mmHg of systolic blood pressure or 90 mmHg of diastolic blood pressure. * Volunteers with blood thyroid stimulating hormone below 0.3 or over 4.0. * Men with hemoglobin below 13.0 g/dl and women with hemoglobin below 12.0 g/dl. * Volunteers with abnormality of liver function as having over 1.5 times of normal levels of ALT or AST. * Patients with infections in upper airways or chronic diseases. * Mental illness patients with such as alcoholism.