In this study, diffusion tensor imaging（DTI）technique was used to evaluate the brain microstructures and connective white matter microstructures in patients with refractory FD, resting fMRI was used to evaluate the functional connectivity between hemispheres, and neuroimaging changes after antidepressant intervention were observed to explore the activation patterns of resting brain homeostasis-receptive network areas in patients with refractory FD. We aimed to explore microstructure of white matter and gray matter and functional connectivity between hemispheres to explain the therapeutic mechanism of antidepressants.
In this study, functional magnetic resonance imaging (fMRI) was used to investigate the abnormal activation patterns of brain regions in patients with refractory FD in resting state, and to observe the changes of brain functions after antidepressant treatment, in order to find scientific evidence for exploring the etiology, neuropathological mechanism and the mechanism of antidepressant treatment of refractory FD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
90
On the basis of routine treatment for 8-12 weeks, according to the characteristics of symptoms, a combination of SSRI or SNRI antidepressant drugs was given for 12 weeks.
Anti-HP, acid suppression, gastrointestinal motility regulation, etc.
2nd Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
RECRUITINGNepean Dyspepsia Index
Evaluation of digestive tract symptoms
Time frame: Change from Baseline at 12th week
Zung Self-Rating Anxiety Scale
It is a scale measures anxiety level of patients including 20 items, and total score ranges from 20 to 80. Higher values represent a worse outcome.
Time frame: Change from Baseline at 12th week
Zung Self-Rating Depression Scale
It is a scale measures depression level of patients including 20 items, and total score ranges from 20 to 80. Higher values represent a worse outcome.
Time frame: Change from Baseline at 12th week
The Pittsburgh Sleep Quality Index
Assessment of Sleep Status
Time frame: Change from Baseline at 12th week
quality of life survey questionnaire
Assessment of quality of life
Time frame: Change from Baseline at 12th week
Incidence of Treatment-Emergent Adverse Events
Record any adverse events during treatment
Time frame: through study completion, an average of 3 years
Functional magnetic resonance imaging
assesses brain microstructures and connective white matter microstructures, and assesses functional connectivity between hemispheres
Time frame: baseline and 12th week
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