Dysbiosis of gut microbiota has been reported to be involved in the development and progression of hypertension in both humans and animal models. Probiotics have been reported to have ameliorative effects in murine models. However, whether probiotics could help alleviate hypertension in adults remain obscure.
Probiotics are live microorganisms that have been associated with multiple health benefits. However, its protective role in adults has long been controversial. This study aims to examine the effect of 12-week probiotics supplementation on the prevention of hypertension in Chinese adults. By understanding the mechanisms by which probiotics exert this beneficial effects, we can better control the rising prevalence of hypertension, which is a major risk factor for cardiovascular diseases.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
40
a commercial probiotic dietary supplement
placebo with a similar appearance to probiotics supplement
Department of Nutrition and Food Hygiene
Guangzhou, Guangdong, China
changes of systolic blood pressure
changes of systolic blood pressure
Time frame: baseline, 4 weeks, 8 weeks and 12 weeks
changes of diastolic blood pressure
changes of diastolic blood pressure
Time frame: baseline, 4 weeks, 8 weeks and 12 weeks
changes of gut microbiota
changes of gut microbiota by metagenomics
Time frame: baseline, 4 weeks, 8 weeks and 12 weeks
changes of pulse wave velocity
changes of pulse wave velocity
Time frame: baseline and after 12-week intervention
changes of ankle brachial index
changes of ankle brachial index
Time frame: baseline and after 12-week intervention
changes of microbial metabolite
changes of microbial metabolite by untargeted metabolomics
Time frame: baseline and after 12-week intervention
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