On day one, two groups of nine patients each will respectively recieve the tree daily meals (breakfast, Lunch and dinner) in a controled clinical setting. Group 1 will recieve a low-salycilate diet, and group 2 a high-salycilate diet. Two hours after each meal, urinary Leucotriene E4, FEV1, FVC, FEV1/FVC and total nasal resistance will be measured. On day 7, after clearance time, group 1 will recieve high-salycilate diet and group 2 low salycilate diet and the same measurements will be obtained.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
15
Each arm of the experimental group will be exposed to low and high concentrations of dietary salycilates and urinary LTE4, FEV1, FVC, FEV1/FVC and total inspiratory nasal resistance will be measured at basal level and then two hours after each of the 3 daily meals.
Instituto Nacional de Enfermedades Respiratorias
Mexico City, Mexico City, Mexico
Change from baseline in Urinary concentration of Leucotriene E4 (LTE4)
pg/ml of creatinine
Time frame: Baseline-4-8-12 hours in day one and Baseline-4-8-12 hours in day 7
Change from baseline in Expiratory Volume in 1 second (FEV-1)
Percentage of referenced value
Time frame: Baseline-4-8-12 hours and Baseline-4-8-12 hours in day 7
Change from baseline in Vital Capacity (FVC)
Percentage of referenced value
Time frame: Baseline-4-8-12 hours and Baseline-4-8-12 hours in day 7
Change from baseline in the Relationship between FEV1/FVC
Percentage of referenced value
Time frame: Baseline-4-8-12 hours and Baseline-4-8-12 hours in day 7
Change from baseline in the total nasal resistance obtained by rhinometry
pascals/cm3/sec
Time frame: Baseline-4-8-12 hours and Baseline-4-8-12 hours in day 7
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