The rate of liver cirrhosis is about 40% to 75% among patients with hepatocellular carcinoma (HCC). Therefore, many patients with HCC were with low serum albumin before and after (especially) hepatic resection. Serum albumin level has been routinely used in clinical practice as a surrogate marker to evaluate nutritional status and liver function. Serum albumin concentration is used as an independent mortality risk predictor in a broad range of clinical and research settings. However, the role of albumin infusion in patients with hepatocellular carcinoma (HCC) after resection is unknown. The present study aimed to investigate the safety and clinical necessity of albumin infusion for HCC patients after hepatic resection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
200
Albumin infusion (20 g, ivgtt, qd) will be performed to patients with HCC after resection in 24 h for three days.
Affiliated Tumor Hospital of Guangxi Medical University
Nanning, Guangxi, China
RECRUITINGJian-Hong Zhong
Nanning, Guangxi, China
NOT_YET_RECRUITINGSerum total bilirubin level
Recovery of liver function between the two groups
Time frame: Change from Baseline total bilirubin at the fifth and seventh days after resection
Serum albumin level
Recovery of liver function between the two groups
Time frame: Change from Baseline serum albumin at the fifth and seventh days after resection
Abdominal girth
Drainage liquid and abdominal girth between the two groups were compared
Time frame: Change from Baseline abdominal girth at the fifth and seventh days after resection
Rate of postoperative complications
The rate of postoperative complications between the two groups were compared
Time frame: The first months after resection
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