Individuals with low copy numbers of salivary amylase gene have lower salivary amylase levels and might therefore have decreased capacity to metabolize starch into glucose. We will in a randomized crossover meal study examine the postprandial response of high-starch meals in individuals with either low or high copy number of the salivary amylase gene.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
23
40 grams of starch in form of white bread to be consumed within 15 minutes
80 grams of starch in form of white bread to be consumed within 15 minutes
Lund University
Lund, Sweden
Postprandial glucose
Postprandial glucose concentration assessed as incremental area under curve over 120 minutes (0, 7, 15, 30, 45, 60 ,90, 120 minutes)
Time frame: AUC (0, 7, 15, 30, 45, 60, 90, 120 minutes)
Postprandial insulin
postprandial insulin concentration assessed as incremental area under curve over 120 minutes (0, 7, 15, 30, 45, 60 ,90, 120 minutes)
Time frame: AUC (0, 7, 15, 30, 45, 60, 90, 120 minutes)
Preabsorptive insulin release
Insulin concentration at 7 minutes
Time frame: 7 minutes
subjective satiety
Visual analog scales (VAS) to evaluate hunger and satiety
Time frame: 0, 15, 30, 45, 60, 90, 120 minutes
salivary amylase activity
Salivary amylase activity will be measured by ELISA kits
Time frame: 0 minutes
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