The aim of this study is the safety and efficacy of autologous very small embryonic-like stem cells(VSELs) to facial skin antiaging.
VSELs come from the patient's peripheral blood, and will be injected in left preauricular area, followed by skin pathology to compare the improvement of skin aging. Two 0.5 × 1 cm fragments of skin and subcutaneous tissue was removed from bilateral preauricular areas for morphologic analysis by optical and electron microscopy. Histologic analysis of skin biopsy specimens was performed by hematoxylin and eosin, picrosirius red (for visualization of collagen), and orcein (for visualization of elastic fibers) staining.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
We carried out the subdermal application of VSELs with a 1-mL syringe (volume, 0.4 mL) coupled to a 30-gauge needle, in the left preauricular area (1-cm2 area), 2 cm distal from the tragus
Biological treatment center in Fuda cancer hospital
Guangzhou, Guangdong, China
Incidence of treatment-emergent adverse events
Swelling in the skin at the injection site
Time frame: 1 week
Incidence of treatment-emergent adverse events
Color change, pain in the skin at the injection site
Time frame: 1 week
Incidence of treatment-emergent adverse events
Pain in the skin at the injection site
Time frame: 1 week
Short-term changes in skin histopathology
Two 0.5 × 1 cm fragments of skin and subcutaneous tissue was removed from the bilateral preauricular areas for morphologic analysis by optical and electron microscopy
Time frame: 3-6 months after injection
Long-term changes in skin histopathology
Two 0.5 × 1 cm fragments of skin and subcutaneous tissue was removed from the bilateral preauricular areas for morphologic analysis by optical and electron microscopy
Time frame: 12 months after final injection
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