Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.

Xijing Hospital of Digestive Diseases1,162 enrolled

Overview

To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.

This study was a multicenter cross-sectional study. Patients were consecutively enrolled and divided into gastric cancer group, gastric precancerous lesions group, and chronic gastritis group, according to histopathological results. The bile reflux detection rate and Helicobacter pylori infection status were recorded for each group.

Study Type

OBSERVATIONAL

Enrollment

1,162

Conditions

Bile Reflux Gastritis Gastric Cancer Helicobacter Pylori Infection Intestinal Metaplasia Precancerous Lesions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18 to 75 years old, gender is not limited; 2. patients with upper abdominal pain, abdominal distension, belching, anorexia, early satiety, hiccup, acid reflux, upper abdomen burning sensation and other upper gastrointestinal symptoms; 3. Voluntary acceptance of Hp testing; 4. Voluntary acceptance of the endoscopy and pathological biopsy. Exclusion Criteria: 1. had undergone upper gastrointestinal surgery; 2. Previous diagnosis of esophageal cancer; 3. Previous diagnosis of gastric cancer; 4. Previous diagnosis of MALT lymphoma; 5. pregnant and lactating women; 6. Those with mental disorders; 7. Refusal to sign the informed consent form.

Locations (1)

Xijing Hosipital of Digestive Disease

Xi'an, Shaanxi, China

Outcomes

Primary Outcomes

corelation between the bile reflux and gastric mucosa diseases

we evaluate the corelation between the bile reflux and gastric mucosa diseases according to the histopathological results and the scales the patients finished

Time frame: up to 6 months

Secondary Outcomes

the risk factors of primary bile reflux gastritis

we evaluate the the risk factors of primary bile reflux gastritis according to the scales and endoscopical results

Time frame: up to 6 months

Data from ClinicalTrials.gov

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