A Randomized Controlled Study of Phacoemulsification by the Enlarged Internal Incision and the Regular 2.2mm Incision

Zhongshan Ophthalmic Center, Sun Yat-sen University294 enrolled

Overview

Objective and Principle: To evaluate whether enlarging the incision can reduce corneal complications associated with phacoemulsification with regular 2.2 mm incision. The aim of this study: To evaluate whether the technique of enlarging internal incision could reduce the incidence of descemet membrane detachment after 2.2 mm incision phacoemulsification. Secondary outcome: To evaluate whether the technique of enlarged internal incision can reduce other corneal complications such as corneal edema and astigmatism after 2.2 mm incision phacoemulsification. Study Design: A prospective randomized controlled study

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

294

Conditions

Cataract

Interventions

enlarged internal incision

Eligibility

Sex: ALLMin age: 65 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age-related cataract patients * Age from 65 to 90 * The diameter of pupil after mydriasis is more than 6 mm * LOCS III nuclear grade ≥4 * Corneal endothelial cell count \> 1500 cells/mm2 * Phacoemulsification and intraocular lens implantation are planned * Agree to participate in this study and sign informed consent Exclusion Criteria: * History of ocular trauma * Anterior segment lesions (exfoliation syndrome, suspension ligament injury or relaxation, corneal and iris lesions, glaucoma) * Other ocular diseases that impair visual function, such as optic neuropathy, uveitis and ocular tumors * History of Ophthalmic Surgery * Intraoperative and Postoperative Complications

Outcomes

Primary Outcomes

descemet membrane detachment(DMD)

DMD at the incision observed by anterior segment optical coherence tomography

Time frame: postoperative 1 week