Treatment of Advanced Gastrointestinal Tumors With Albumin Taxol

Inclusion Criteria: 1. Patients aged ≥18 years with advanced esophageal cancer, gastric cancer, pancreatic cancer and gallbladder (duct) confirmed histologically by albumin paclitaxel chemotherapy regimen; 2. ECOG PS 0-2； 3. Expected survival time ≥3 months; 4. According to RECIST1.1, at least one measurable lesion exists； 5. The level of organ function must meet the following requirements（1）Blood routine examination standards must be met：HB≥90 g/L；ANC≥1.5×109/L； PLT≥80×109/L；（2）Liver function should meet the following criteria TBIL≤1.5×ULN；AST≤2.5×ULN；（3）Renal function should meet the following criteria: CrCL≥60 ml/min； Exclusion Criteria: 1. Pregnant or lactating women； 2. Had a history of other primary malignancies within 5 years, with the exception of cured basal cell skin cancer and cured cervical cancer; 3. Active brain metastasis or severe disease; 4. Grade 1 peripheral neuropathy (judged according to NCICTC standard for adverse reactions); 5. Patients with allergy to research drugs, albumin or previous allergies; 6. Severe mental or neurological disorders affecting the presentation or observation of adverse reactions; 7. The investigator considers that there is any condition that may impair the subject or cause the subject to fail to meet or perform the study requirements.