This study is a single-center, open-label, single-dose design. It is planning to enroll six Chinese healthy adult male subjects. The metabolism and disposition of Herombopag, will be studied in these subjects after a single oral administration of a solution dose of \[14C\] Herombopag (5 mg, 100 uCi).
The metabolism and disposition of Herombopag, will be studied in six healthy men after a single oral administration of a solution dose of \[14C\]eltrombopag (5 mg,100 uCi). The sutdy will investigate total radioactivity pharmacokinetics in whole blood and plasma 、quantitatively analyze the the total radioactivity in the excreta、evaluate the predominant route of elimination and indentify the Metabolite profiles in plasma 、urine and faces.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
6
a single oral taking
The first affiliated hospital of Suzhou university
Suzhou, Jiangsu, China
Total radioactivity pharmacokinetics in whole blood and plasma
plasma concentration of total radioactivity
Time frame: From 1 hour before administration to 240 hours after administration
total radioactivity in the excreta
Excretion of radioactivity in human urine and feces
Time frame: From 24 hour before administration to 336 hours after administration
the concentration of Hetrombopag in plasma
Area under the plasma concentration versus time curve (AUC)
Time frame: From 1 hour before administration to 240 hours after administration
individual metabolite profiles in plasma 、urine and faces
Using quantitative High Performance Liquid Chromatography-Mass Spectroscopic method to analyse individual percentage of metabolites.
Time frame: From 24 hour before administration to 336 hours after administration
mean metabolite profiles in plasma 、urine and faces
Using quantitative High Performance Liquid Chromatography-Mass Spectroscopic method to analyse mean percentage of metabolites.
Time frame: From 24 hour before administration to 336 hours after administration
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