Early Maladaptive Schemas (EMS) are overactivated in euthymic bipolar disorders (BD) and are associated with poor psychosocial functioning and higher suicidality. The first objective of this study is to establish different clusters of EMS in euthymic bipolar disorders, compare these clusters according to the clinical characteristics of BD and neuropsychological performances and evaluate the temporal stability of these clusters at 12 and 24 months. The second objective of this study is to quantify the impact of EMS on functioning in euthymic BD, beyond the effect of cognition and residual depressive symptoms.
Early Maladaptive Schemas (EMS) are overactivated in euthymic bipolar disorders (BD) and are associated with poor psychosocial functioning and higher suicidality. However, few studies have explored EMS in bipolar disorders, despite EMS therapy is a promising tool for the psychotherapy of BD. This study will use the data collected at the Versailles Expert Center for Bipolar disorder, in the local FACE-BD registry. These data will be collected at the inclusion, 12 months and 24 months later. They included an extensive neuropsychological battery and an extensive evaluation of the clinical characteristics of bipolar disorder. EMS will be measured with the Young Schema Questionnaire Short Form 3. The first objective of this study is to establish different clusters of EMS in euthymic bipolar disorders, compare these clusters according to the clinical characteristics of BD and neuropsychological performances and evaluate the temporal stability of these clusters at 12 and 24 months. The second objective of this study is to quantify the impact of EMS on functioning in euthymic BD, beyond the effect of cognition and residual depressive symptoms.
Study Type
OBSERVATIONAL
Enrollment
150
Paul ROUX
Le Chesnay, France
RECRUITINGEarly Maladaptative Schemas T0
distance to the norm for the scores on each 18 early maladaptative schema measured with the Young Shema Questionnaire short form 3, no lower bound limit, no upper bound limit, a low score indicate a lower activation of the Early Maladaptative Schema
Time frame: 18 measures by subject, assessed at inclusion
Early Maladaptative Schemas T12
distance to the norm for the scores on each 18 early maladaptative schema measured with the Young Shema Questionnaire short form 3, no lower bound limit, no upper bound limit, a low score indicate a lower activation of the Early Maladaptative Schema
Time frame: 18 measures by subject, assessed at 12 months
Early Maladaptative Schemas T24
distance to the norm for the scores on each 18 early maladaptative schema measured with the Young Shema Questionnaire short form 3, no lower bound limit, no upper bound limit, a low score indicate a lower activation of the Early Maladaptative Schema
Time frame: 18 measures by subject, assessed at inclusion 24 months
functioning
total score on the Functioning Assessment Short Test (lower bound 0 upper bound 72, lower scores indicates better functioning)
Time frame: one measure by subject, assessed 3 times (inclusion, 12 months and 24 months)
Depression
total score on the Montgomery Åsberg Depression Rating Scale (minimum 0 maximum 10)
Time frame: one measure by subject, assessed 3 times (inclusion, 12 months and 24 months)
Cognition
distance to the norm for the scores for each the five cognitive dimension measured with the standardised neuropsychological battery, no lower bound limit, no upper bound limit, lower scores indicate poorer cognition
Time frame: 5 measures by subject, assessed 2 times (at inclusion and 24 months)
Hypomania
total score on the Young Mania Rating Scale (lower bound 0 upper bound 12, lower scores indicate lower hypomania
Time frame: one measure by subject, assessed 3 times (inclusion, 12 months and 24 months)
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