Early glaucomatous visual field changes can be missed with the routinely used Standard Automated Perimetry (SAP) and the 24-2 test pattern due to limited sampling of the central 10 degrees. While this shortcoming can be overcome with the addition of a 10-2 test, performing both tests places extra demand on the perimetric services (doubling test times) and patients. Smart Supra Perimetry (SSP) uses a new faster algorithm that can complete both 24-2 and 10-2 test patterns in a similar time frame to a single 24-2 SAP test. This comparative study aims to determine the sensitivity and specificity (i.e. diagnostic accuracy) of SSP in identifying early glaucomatous visual field loss. A sample of 100 patients with early/suspect glaucoma will undergo SAP 24-2 and 10-2 (SITA algorithm) using Humphrey visual field perimetry and SSP 24+10-2 using Henson 9000. Eyes will be categorised into 2 groups i.e., glaucoma and non-glaucoma, on the basis of structural changes to the disc as evaluated by the clinician. The sensitivity and specificity of the SAP and SSP tests will be established along with test duration. The size and location of defects established with both the SAP and SSP strategies will also be compared.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
100
SITA Standard and 24-2 and 10-2 visual field tests
Circle and Wide Angle Scans
24+10-2 Smart Supra test
Manchester Royal Eye Hospital
Manchester, United Kingdom
Diagnostic performance of smart supra perimetry
Area under the curve for Smart Suprathrold Perimetry using probability thresholds to differentiate early glaucoma from non-glaucomatous visual fields.
Time frame: 12 months
Diagnostic performance of Optical Coherent Tomography
Sensitivity and specificity for Optical Coherent Tomography in the detection of early glaucoma.
Time frame: 12 months
Diagnostic performance of Standard Automated perimetry
Sensitivity and specificity for Standard Automated perimetry in the detection of early glaucoma.
Time frame: 12 months
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