Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation

Central Hospital, Nancy, France39 enrolled

Overview

Thrombocytopenia is a frequent and serious adverse event in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock. Similarly to postcardiac surgery patients, heparin-induced thrombocytopenia (HIT) could represent the causative underlying mechanism. However, the epidemiology as well as related mortality regarding HIT and VA-ECMO remains largely unknown. The investigators aimed to define the prevalence and associated 90-day mortality of HIT diagnosed under VA-ECMO.This retrospective study included patients under VA-ECMO from 20 French centers between 2012 and 2016.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heparin-induced Thrombocytopenia

Interventions

Hospitalization for more than 3 days with high clinical suspicion of HIT and positive anti-PF4/heparin antibodiesOTHER

Patients are classified according to results of functional tests as having either Confirmed or Excluded HIT.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years * Patient hospitalized in intensive care for a cardiovascular failure requiring the setting up of an ECMO-VA * ECMO-VA duration ≥ 3 days * HIT confirmed by immunological tests * Patient affiliated to a Social Security scheme Exclusion Criteria: * Known antecedent of TIH prior to cannulation * Pregnant woman * ECMO-VA following cardiopulmonary arrest or septic shock

Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes