The study is a case-controlled observational trial. Forty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night Bispectral index data. Firstly, this study aims to characterise the lung microbiota in patients treated with thyroid surgery. Secondly, it aims to evaluate microbiota and its influence on plasma kynurenine.
The study is a case-controlled observational trial. Forty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night Bispectral index data. Firstly, this study aims to characterise the lung microbiota in patients treated with thyroid surgery. Secondly, it aims to evaluate microbiota and its influence on plasma kynurenine.
Study Type
OBSERVATIONAL
Enrollment
33
For maintenance of propofol anesthesia, total intravenous anesthesia was administered by using propofol (Fresenius Kabi, Austria GmbH) at a plasma target concentration (Marsh pharmacokinetic model software) of 2.5-4 μg/ml. Remifentanil (0.2-0.5 μg/kg/min) was given to all patients during the operation.
the First Hospital of China Medical University
Shenyang, Liaoning, China
gut microbiota
this study will characterise the gut microbiota in 2 groups of 30 patients.
Time frame: the first postoperative night
Bispectral index data
this study will characterise the Bispectral index data in 2 groups of 30 patients
Time frame: the first postoperative night
plasma kynurenine concentrations
this study will characterise the plasma kynurenine concentrations in 2 groups of 30 patients
Time frame: baseline and the first postoperative night
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