NCT03982251 - The Effects of Whole Body Vibration in People With Chronic Stroke | Crick

Overview

Whole body vibration (WBV) has been found to be useful in promoting bone health and muscle performance in older adults. To date, no study has examined the effects of different WBV frequencies on the properties of the muscle-bone unit in stroke patients. The overall aim of the proposed study is to compare the efficacy of different vibration frequencies on properties of the muscle function and bone turnover among people with chronic stroke. It is hypothesized that the higher-vibration frequency protocol will lead to significantly better outcomes related to the bone turnover and muscle function.

Whole body vibration (WBV) has been found to be useful in promoting bone health and muscle performance in older adults. To date, no study has examined the effects of different WBV frequencies on the properties of the muscle-bone unit in stroke patients. The overall aim of the proposed study is to compare the efficacy of different vibration frequencies on properties of the muscle function and bone turnover among people with chronic stroke. It is hypothesized that the higher-vibration frequency protocol will lead to significantly better outcomes related to the bone turnover and muscle function in people with chronic stroke.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

80

Conditions

Stroke

Interventions

High frequency whole body vibrationPROCEDURE

1 single session ( 8 minutes) of whole body vibration therapy at 30 Hz

Low frequency whole body vibrationPROCEDURE

1 single session ( 12 minutes) of whole body vibration therapy at 20 Hz

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. a diagnosis of stroke 2. stroke onset \>6 months 3. \>18 years of age 4. able to walk for short distance independently with or without walking aid 5. able to understand simple verbal commands Exclusion Criteria: 1. neurological conditions other than stroke 2. significant musculoskeletal conditions (e.g. amputations) 3. metal implants in the lower extremity 4. previous fracture of the lower extremity 5. are currently taking bone resorption inhibitors or were taking the same before stroke. 6. significant peripheral vascular disease 7. vestibular disorders 8. pregnancy 9. Other serious illnesses that preclude the person from participating in the study

Locations (1)

The Hong Kong Polytechnic University

Hong Kong, Hong Kong

Outcomes

Primary Outcomes

bone resorption marker

Serum level of aminoterminal crosslinked telopeptide

Time frame: pre-test (week 0)

bone resorption marker

Serum level of aminoterminal crosslinked telopeptide

Time frame: post-test (week8)

Secondary Outcomes

Six Minute Walk Test

endurance test

Time frame: pre-test (week 0)

Six Minute Walk Test

endurance Test

Time frame: post-test (week8)

Gait velocity

10-meter walking test

Time frame: pre-test (week 0)

Gait velocity

10-meter walking test

Time frame: post-test (week8)

Spasticity

H-reflex on tibial nerve and modified ashworth scale

Time frame: pre-test (week 0)

Spasticity

H-reflex on tibial nerve and modified ashworth scale

Time frame: post-test (week8)