TQLB for Postoperative Pain After Laparoscopic Partial Nephrectomy

Cui Xulei60 enrolled

Overview

This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay，et al. between single-injection QLB(quadratus lumborum block)+ intravenous patient-controlled analgesia (IPCA) and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing laparoscopic partial nephrectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Laparoscopic Renal Surgery Pain Management Nerve Block

Interventions

single-injection TQLB(transmuscular quadratus lumborum block)PROCEDURE

Inject 0.6ml/kg local anesthetics in between quadratus lumborum and psoas major under ultrasound guidance

Morphine given as IPCA(intravenous patient controlled analgesia)DRUG

PCIA was initiated using a pump set to deliver boluses of 1.5-2 mg of morphine with a 5-minute lockout interval and no background infusion. The maximal permitted dosage of morphine was set at 8 mg/h.

Eligibility

Sex: ALLMin age: 17 YearsMax age: 80 Years

Medical Language ↔ Plain English

inclusion Criteria: * Age 18-70 yrs * American Society of Anesthesiologists physical statusⅠ-Ⅲ * Undergo laparoscopic partial nephrectomy * Informed consent Exclusion Criteria: * A known allergy to the drugs being used * Coagulopathy, on anticoagulants * Analgesics intake, history of substance abuse * Participating in the investigation of another experimental agent * Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Locations (1)

Cui Xulei

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

cumulative morphine consumption 8 hours after surgery

Time frame: at the 8 hours after surgery

Secondary Outcomes

cumulative morphine consumption at other time points after surgery

Time frame: at 0, 2, 4, 12, 24 and 48 hours after surgery

The pain scores(at rest or on activity) determined by the numeric rating scale (NRS, 0-10)

NRS is an internationally recognized pain scale with 11 points ranging from 0 to 10 points, with 0 defined as no pain and 10 defined as the worst pain imaginable.

Time frame: at 0, 2, 4, 8,12, 24, 48 and 72 hours after surgery

episodes of nausea and vomiting

Time frame: within 24 hours after the surgery

ambulation time

time from the end of the surgery to the first time to out-of-bed activity

Time frame: within the 5 days after surgery

time of recovery of bowl movement

time from the end of the surgery to the first time of bowl movement

Time frame: within the 5 days after surgery

patient satisfaction with anesthesia

Patient satisfaction with anesthesia was assessed using a 5-point scale (5: very satisfied; 4: satisfied; 3: neither satisfied nor dissatisfied; 2: dissatisfied; 1: very dissatisfied)

Time frame: at 48 hours after surgery

quality of recovery evaluated by the self-assessment 15-item quality of recovery (QoR) scale

QoR is a 15-item questionnaire which will score on a scale of 0-10 pertaining to patient's comfort, support system, pain, well-being, and ability to carry out daily activities, where 0 indicates none of the time and 10 indicates all of the time

Data from ClinicalTrials.gov

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