The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with Multiple Sclerosis.
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with Multiple Sclerosis (MS). The study is designed to research how well this technique can help people with MS improve their memory and their ability to function better in everyday life.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
120
Protocol designed to improve memory functioning in individuals with neurological injuries administered for 4 weeks (8 training sessions).
Placebo control memory exercises will be administered for 4 weeks (8 training sessions).
Kessler Foundation
East Hanover, New Jersey, United States
Kessler Rehabilitation Center
Marlton, New Jersey, United States
Changes in scores on self-report measure of everyday cognition (subjective)
Perceived Deficits Questionnaire
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in scores on self-report measure of everyday cognition (objective)
Ecologic Memory Simulations
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in auditory processing speed
Paced Auditory Serial Edition Test
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in information processing speed
Symbol Digit Modalities Test
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in episodic verbal memory and learning
California Verbal Learning Test - 2nd Edition
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in visuospatial memory
Brief Visuospatial Memory Test - Revised
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in ability in spontaneous production of words
Controlled Oral Word Association Test
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Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in visual perception
Benton Judgment of Line Orientation
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in executive function
Delis-Kaplan Executive Function System - Sorting
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)