Chronic fatigue is the most common and debilitating symptom in multiple sclerosis patients. This chronic fatigue affects their quality of life by decreasing their capacity to perform simple tasks of daily life. The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in this feeling of chronic fatigue. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology will allow to optimize rehabilitation treatments to decrease the apparition/persistence of chronic fatigue and in fine improve quality of life.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
67
Evaluation of degree chronic fatigue with the results of survey Fatigue Severity Scale (FSS) and Modified Fatigue Impact Scale (MFIS). This result will allow to divide patients in groups : lowly fatigued and highly fatigued.
* Fatigue Severity Scale (FSS) * Modified Fatigue Impact Scale (MFIS) * Godin Leisure-Time Exercise Questionnaire (GLTEQ) * Scale of life quality of multiple sclerosis (SEP-59) * Center for Epidemiologic Studies Depression (CES-D) * Pittsburgh Sleep Quality Index (PSQ-I)
Blood sample will be realized to evaluate anemia and inflammations.
Cardiopulmonary evaluation will be realized with a cycle ergometer.
Measure the capacity of muscular oxygen extraction with a cycle ergometer.
Sleep assessment will be measured by actigraphy during 15 days.
Metabolic fatigue will be measured by Magnetic Resonance Imaging (MRI).
Neuromuscular evaluation will be measured by the composite of the results of: * Fatigue test * Measure of voluntary isometric force * Surface electromyography * Peripheral nerve stimulation * Transcranial Magnetic Stimulation (TMS) * Perceived fatigue * Cognitive fatigue * Thermoregulation
Chu Saint-Etienne
Saint-Etienne, France
Voluntary maximum contraction
Comparison the percentage of decrease in voluntary maximum contraction reported after the fatiguing task. Measured by an instrumented measuring pedal (PowerForce pedal, Model PF1.0.0.0, Radlabor GmbH, Freiburg, Germany)
Time frame: Day : 30
Neuromuscular function during the dynamic strenuous exercise
Cortical activity by transcranial magnetic stimulation, evaluated by recording of the evoked motor potentials .
Time frame: Day : 30
Muscle oxygen extraction capacity
Measured by near-infrared spectroscopy (NIRS)
Time frame: Day : 30
Anemia
Measured by blood count in blood sample
Time frame: Day : 30
Inflammation
Measured by C-reactiv protein in blood sample
Time frame: Day : 30
VO2 max
Measured by effort test
Time frame: Day : 30
Heart rate
Measured by heart rate monitor
Time frame: Day : 30
Cognitive fatigue
Measured by Symbol Digit Modalities Test
Time frame: Day : 30
Perceived fatigue
Measured by Borg scale
Time frame: Day : 30
Thermoregulation
Measured by digestible thermometric pill (e-celcius Performance)
Time frame: Day : 30
Sleep quality
Measured by actigraphy
Time frame: Day : 30
Muscle volume
Measured by Magnetic Resonance Imaging
Time frame: Day : 30
Metabolic fatigue
Measured by a Phosphorus 31 Nuclear Magnetic Resonance test
Time frame: Day : 30
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.