Therapeutic bronchoscopy is a common procedure to treat respiratory diseases. The procedure includes stent implantation, bronchus dilation, electronic incision, laser therapy, and so on. Most of these procedures are painful and require general anesthesia. Conventionally, the general anesthesia for therapeutic bronchoscopy was performed using laryngeal mask. But in the previous experiences, the investigators found that sedation with dexmedetomidine and remifentanil was as effect as laryngeal mask anesthesia. The present study was performed to compare the two approach for sedation or anesthesia in therapeutic bronchoscopy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
Dexmedetomidine was used as a sedation agent with less side effect on respiratory system.
Remifentanil was used to prevent cough induced by bronchoscopy.
Laryngeal mask was used to ensure respiration function during general anesthesia.
Faculty of Anesthesiology, Changhai Hospital
Shanghai, Shanghai Municipality, China
Recovery time
Duration of the recovery from sedation
Time frame: After termination of the sedation medication, assessed up to 3 hours
Satisfaction score of the patients and bronchoscopists
Satisfaction score of the patients and bronchoscopists regarding to the sedation quality measured by a 0-100 visual analogue scale (VAS). 100 refers to the highest satisfaction degree while 0 refers to the worst satisfaction degree.
Time frame: Across the procedure, assessed up to 3 hours
Prevalence of the side effects of respiratory and circulatory system
The number of the side effects in respiratory and circulatory system during the procedure, including hypertension, hypotension, tachycardia, bradycardia, hypoxia and larynx spasm.
Time frame: Across the sedation or anesthesia, assessed up to 3 hours
Cost of anesthesia or sedation
Time frame: Across the sedation or anesthesia, assessed up to 3 hours
Cough score
Cough score across the procedure will be classified into 4 degree (1-4) as follows. 1 = none, 2 = one gag or cough only, 3 = \>1 gag or cough, but acceptable conditions, 4 = unacceptable conditions
Time frame: From the completion of local anesthesia with lidocaine to the completion of bronchoscopy procedure, assessed up to 3 hours
The numbers of the times of body movement
The numbers of the times of any body movement across the procedure
Time frame: From the completion of local anesthesia with lidocaine to the completion of bronchoscopy procedure, assessed up to 3 hours
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