The aim of this study is the safety and efficacy of autologous very small embryonic-like stem cells(VSELs) to premature ovarian failure.
Premature ovarian failure is diagnosed by blood femal hormones test of follicle stimulating hormone (FSH, \> 40 IU/L)、luteinizing hormon (LH, \> 40 IU/L)、estradiol (E2, \> 100pg/mL) and/or amenorrhea before the age of 40. VSELs come from the patient's periperal blood, and will be injected in bilateral oviducts, followed-up by hormone testing and menstrual conditions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Mononuclear cells were collected from peripheral blood of each patient using a machine, VSELs were isolated, and each group was injected according to different numbers after activation
Biological treatment center in Fuda cancer hospital
Guangzhou, Guangdong, China
Concentration of Blood female hormones level
Check whether blood FSH, LH and E2 levels return to normal
Time frame: 1 month after injection
Concentration of Blood female hormones level
Check whether blood FSH, LH and E2 levels return to normal
Time frame: 6 months after injection
Incidence of amenorrhea
Inquire about menstrual condition and exam ovarian blood supply by gynecological color ultrasound
Time frame: 6 months after injection
Concentration of Blood female hormones level
Check whether blood FSH, LH and E2 levels return to normal
Time frame: 12 months after injection
Incidence of amenorrhea
Inquire about menstrual condition and exam ovarian blood supply by gynecological color ultrasound
Time frame: 12 months after injection
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