The study is a case-controlled observational trial. Sixty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night Bispectral index data. Firstly, this study aims to characterise the gut and lung microbiota in patients with lung cancer treated with surgery. Secondly, it aims to evaluate microbiota and its influence on plasma kynurenine.
The study is a case-controlled observational trial. Sixty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night Bispectral index data. Firstly, this study aims to characterise the gut and lung microbiota in patients with lung cancer treated with surgery. Secondly, it aims to evaluate microbiota and its influence on plasma kynurenine.
Study Type
OBSERVATIONAL
Enrollment
20
For maintenance of propofol anesthesia, total intravenous anesthesia was administered by using propofol (Fresenius Kabi, Austria GmbH) at a plasma target concentration (Marsh pharmacokinetic model software) of 2.5-4 μg/ml. Remifentanil (0.2-0.5 μg/kg/min) was given to all patients during the operation. Additional cisatracurium （0.05 mg/kg）and fentanyl (30-50 μg at the end of surgery) were used as needed, in accordance with the clinical requirements.
the First Hospital of China Medical University
Shenyang, Liaoning, China
lung and gut microbiota
this study will characterise the lung and gut microbiota in 2 groups of 30 patients
Time frame: from baseline to postoperative 72 hours
Bispectral index data
this study will characterise the Bispectral index data in 2 groups of 30 patients
Time frame: the first postoperative night
plasma kynurenine concentrations
this study will characterise the plasma kynurenine concentrations in 2 groups of 30 patients
Time frame: baseline and the first postoperative night
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.