This randomized, single-center, prospective study seeks to compare the conventional radial approach with the recently described distal radial approach (anatomical snuffbox) concerning the patency of the radial artery in patients subjected to coronary angiography or percutaneous coronary intervention.
Transradial approach has become the standard approach for coronary angiography (CAG) and percutaneous coronary intervention (PCI). The current ESC/EACTS guidelines of myocardial revascularization support using radial approach (RA) rather than femoral approach (FA) if the operators are experts for RA. Recently, an alternative transradial access has been suggested at the anatomical snuffbox, with potential additional benefits including a reduction in radial artery occlusion rate (which allows reintervention through the same access site and potential use as a graft), a decrease in other local vascular complications, shorter hemostasis duration, patients' intra and post procedural comfort and shorter recovery time. However, the feasibility of PCI via snuffbox approach is still concerned due to the lack of data. Therefore, the aim of the study is to compare the two approaches concerning the patency of the radial artery ≥30 days after the intervention with Doppler in a randomized way. Due to the anastomosis of the distal radial artery with the superficial palmar arch, even in case of total radial artery occlusion within the anatomical snuffbox, the antegrade blood flow may be preserved and, therefore, decreased incidents of radial artery occlusion are expected in the right distal radial artery approach group. The mean diameter of radial artery at the anatomical snuffbox is 2.4 mm, whereas the mean diameter of the radial artery at the forearm is 2.7 mm, and this could potentially contribute to shorter hemostasis duration.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
1,042
Comparison of the conventional radial approach with the distal radial approach (anatomical snuffbox)
University Hospital of Patras
Pátrai, Achaia, Greece
Rate of right radial artery occlusion
Time frame: ≥30 days after CAG or PCI
Rate of successful insertion of the sheath
Time frame: Immediately post-procedurally
Duration of sheath insertion procedure
Time frame: Immediately post-procedurally
Rate of successful completion of coronary angiography
Time frame: Immediately post-procedurally
Rate of successful completion of percutaneous coronary intervention
Time frame: Immediately post-procedurally
Total Contrast volume
Time frame: Immediately post-procedurally
Total Fluoroscopy time
Time frame: Immediately post-procedurally
Total Radiation Dose
Time frame: Immediately post-procedurally
Total Procedure Time
Time frame: Immediately post-procedurally
Time required for hemostasis
Time frame: 1-6 hours
Postprocedural Hematoma (modified EASY class)
Time frame: 3 hours
Rate of distal radial artery occlusion
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Time frame: ≥30 days after CAG or PCI
Pain associated with the procedure: Pain scale 0-10
Pain scale 0-10. A visual anlog pain scale 0-10 will be shown to the patient post-precedurally. 0=no pain, 10=worst pain. Patient will be asked to report the severity of the pain associated with the procedure.
Time frame: 1 hour