Apatinib Plus SHR1210 in Advanced Mucosal Melanoma

Inclusion Criteria: * mucosal melanoma by pathology * expected lifespan ≥ 3 months * ECOG 0-2 * failure after one kind of chemotherapeutic regimen * at least one measurable lesion by RECIST 1.1 * enough organ function * blood pressure is normal; for patients with hypertension the blood pressure should be controlled in normal by antihypertensive drugs * no other serious diseases conflicting with this regimen * no history of other malignancies * pregnancy test within 7 days must be negative for women of childbearing period, and appropriate measures should be taken for contraception for women in childbearing period during the study and six months after this study * informed consent from the patient Exclusion Criteria: * Suffering from serious infectious diseases within 4 weeks before enrollment * requiring intermittent use of bronchodilators or medical interventions * usage of immunosuppressants before enrollment and the dose of immunosuppressant used ≥ 10mg / day oral prednisone for more than 2 weeks * serious allergy * serious mental diseases * abnormal coagulation funtion,bleeding tendency or receiving thrombolytic or anticoagulant therapy * abdominal fistula, gastrointestinal perforation, or abdominal abscess within 4 weeks prior to enrollment * previous or current pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, severe lung damage, etc. * other situations evaluated by investigator unsuitable for this study