The study of volatile organic compounds (VOC) detected in exhaled air or in sweat, is an innovative research area for respiratory diseases. The volatolomic analysis can be done either by the technique of the mass spectrometry which allows the identification of each VOC in the exhaled air or by the technique of electronic nose, simpler and faster, which provides an idea of the general profile of the VOC without identifying them. The VOC have shown their interest in some situations, such as diagnostic or prognostic tool in patients followed for thoracic tumorous pathology or bronchial or pulmonary vascular diseases. Immunotherapy is a new therapeutic approach used in non small cell lung cancer in a late stage. VOC analysis could allow to identify biomarkers of early response to immunotherapy. The study of VOC could help in the optimisation of immunotherapy prescription in lung cancer.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
60
VOC analysis in exhaled air with e-noses and mass spectrometry.
Hôpital Foch
Suresnes, France
Profiles of Volatil Organic Compound (VOC) in exhaled air
Comparison of variation of Volatil Organic Compound (VOC) profiles in exhaled air of patients before and during immunotherapy
Time frame: 1 day
Variation of Volatil Organic Compound (VOC) in exhaled air
Correlation of variation with response to immunotherapy at week 9, 18 and 27 (according to RECIST criteria)
Time frame: change from baseline profiles at week 9, week 18 and week 27 post-baseline
Profiles of Volatil Organic Compound (VOC) in sweat
Comparison of variation of Volatil Organic Compound (VOC) profiles in sweat of patients before and during immunotherapy
Time frame: 1 day
Variation of Volatil Organic Compound (VOC) in sweat
Correlation of variation with response to immunotherapy at week 9, 18 and 27 (according to RECIST criteria)
Time frame: change from baseline profiles at week 9, week 18 and week 27 post-baseline
Volatil Organic Compound (VOC) profile and radiological response
Correlation between Volatil Organic Compound (VOC) profile before treatment and radiological response at 9, 18 and 27 weeks (defined by RECIST criteria)
Time frame: change from baseline profiles at week 9, week 18 and week 27 post-baseline
Volatil Organic Compound (VOC) profile and drug toxicity
Correlation between variation of Volatil Organic Compound (VOC) profiles and apparition of drug toxicity at 9, 18 and 27 weeks
Time frame: change from baseline profiles at week 9, week 18 and week 27 post-baseline
Comparison of performance from Volatil Organic Compound (VOC) from exhaled air versus sweat
Comparison of performance of Volatil Organic Compound (VOC) from exhaled air versus Volatil Organic Compound (VOC) from sweat
Time frame: 1 day
Comparison of performance of mass spectrometry versus electronic noses
Comparison of performance of Volatil Organic Compound (VOC) from mass spectrometry versus Volatil Organic Compound (VOC) from electronic noses
Time frame: 1 day
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