Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause. Many triggers of rosacea symptoms are stressors that affect the sympathetic ("fight or flight") portion of the nervous system, and a recent pilot study suggests there is sympathetic dysfunction in rosacea. This project will benefit patients, clinicians, and basic scientists by increasing our understanding of sympathetic nervous system involvement in rosacea symptoms in order to develop improved treatments for patients with rosacea.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
40
Protocol 1: skin sympathetic nerve activity will be measured during mental math and handgrip exercise. Protocol 2: skin end organ responses will be measured at baseline and in response to systemic stressors and end-organ receptor stimulation. Protocol 3: skin end organ responses will be measured at baseline and during local heating.
Indiana University
Indianapolis, Indiana, United States
University of Kentucky
Lexington, Kentucky, United States
Skin blood flow
laser Doppler flowmetry
Time frame: Immediate (during the single-day study). This study consists of a one-day protocol, during which this outcome is measured.
Skin sympathetic nerve activity
microneurography
Time frame: Immediate (during the single-day study). This study consists of a one-day protocol, during which this outcome is measured.
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