Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement

Swiss Federal Institute of Technology14 enrolled

Overview

Polyphenolic compounds are very strong Inhibitors of non-heme iron absorption, as they form insoluble complexes with ferrous iron. Patients with hereditary hemochromatosis (HH) have an increased intestinal non-heme iron absorption due to a genetic mutation in the regulatory pathway, leading to excess iron in the body. This study investigates the inhibitory effect of a natural polyphenol Supplement in participants with HH.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Iron Metabolism Disorders Iron Overload Polyphenols

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Homozygous for C282Y mutation in HFE (hemochromatosis) gene * Written informed consent * Age 18-65 y * Not pregnant or lactating * Body weight \< 75 kg * Body mass index (BMI) between 18.5 and 25 kg/m2 * No acute illness/infection (self-reported) * No metabolic or gastrointestinal disorders, eating disorders or food allergy to the ingredients of the test meal (self-reported) * No scheduled phlebotomy throughout the study period * The last phlebotomy will be at least 4 weeks prior first test meal administration * No use of medications affecting iron absorption or metabolism during the study * No intake of mineral/vitamin supplements 2 weeks before the first study day and during the study * Participation in any other clinical study within the last 30 days * Expected to comply with study protocol

Outcomes

Primary Outcomes

change from baseline in the isotopic ratio of iron in blood at week 2

The change in the isotopic ratio of iron will be measured after administration of a test meal/drink including iron isotopes

Time frame: baseline, 2 weeks

change from baseline in the isotopic ratio of iron in blood at week 4

The change in the isotopic ratio of iron will be measured after administration of a test meal/drink including iron isotopes

Time frame: 2 weeks, 4 weeks