The PowerSpiral Antegrade Investigational Device Exemption (IDE) Study

Inclusion Criteria: * Patient is ≥ 22 years of age * Medical indication for antegrade enteroscopy * Willing and able to provide informed consent Exclusion Criteria: * Any medical contraindication to standard enteroscopy * Any test that is done as part of the standard of care that would prevent the enteroscopy from being performed for safety reasons * Unable or unwilling to provide informed consent * Female and of child-bearing age who is currently pregnant or planning to become pregnant within the study period * Presence of any intra-luminal or extra-luminal foreign body in the abdominal cavity * Any prior gastric, small bowel or colonic surgery, or implantable devices in these locations (cardiac pacemakers and non-abdominal implants are acceptable) * Known or suspected bowel obstruction, or history of bowel obstruction * Taking anti-platelet agents or anticoagulants (other than aspirin) within last 7 days * Known coagulation disorder * Known or suspected esophageal stricture or Schatzki ring * Known gastric or esophageal varices * Suspected perforation of the gastrointestinal (GI) tract * Previous abdominal radiation * Inability to tolerate general anesthesia for any reason * Inability to tolerate endotracheal intubation * Known need for endoscopic retrograde cholangiopancreatography (ERCP) during enteroscopy * American Society of Anesthesiologists (ASA) Classification 4 or greater