Clinical Outcomes for Deep Brain Stimulation

Washington University School of Medicine1,000 enrolled

Overview

The object of this study is to longitudinally collect clinical outcomes of patients receiving deep brain stimulation for movement disorders with the objective of making retrospective comparisons and tracking of risks, benefits, and complications.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Parkinson Disease Essential Tremor Dystonia

Interventions

Deep Brain StimulationDEVICE

High frequency electrical stimulation of deep brain nuclei for the treatment of movement disorders

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Levodopa responsive Parkinson disease OR * Medically refractory Essential Tremor OR * Medically refractory Dystonia Exclusion Criteria: * Dementia (Mattis Dementia Rating Scale \<130) * Structural abnormalities precluding intracranial surgery

Locations (1)

Washington University in St Louis

St Louis, Missouri, United States

RECRUITING

Outcomes

Primary Outcomes

UPDRS

United Parkinson's Disease Rating Scale (global assessment of motor, non-motor, and quality of life associated with symptoms of Parkinson disease). Total scores range from 0-199. Particular emphasis is paid to subsection 3 (motor), where scores range from 0-56.

Time frame: Change in UPDRS at 1 year after DBS (from preoperative baseline).

Central Contacts

Mwiza Ushe, M.D.

CONTACT

3143625262 ushem@wustl.edu

Data from ClinicalTrials.gov

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