Borderline Personality Disorder (BPD) is a common psychiatric disorder occurring in 2 to 6% of the population. 70% of patients with BPD do at least one Suicide Attempt (SA) in their lives. It makes BPD the most related to SA condition. Negative interpersonal events are among the main stressor inducing a SA. Patients with BPD are characterized by emotional dysregulation, impulsivity (repeated parasuicidal and suicidal behaviors), and instability in interpersonal relationships. The feeling of shame related to this psychiatric disorder could be one of the causes of the high SA rate. In this study, patients with BPD will be follow-up during 5 years. The main objective is to study the propensity to feel shame as a predictor of SA. This include: * Study of shame propensity as a predictive factor of suicidal behavior - Identify homogeneous subgroups of patients with BPD based on SA, and overall functioning. * Identify biological markers predicting SA * Identify predictive and protective treatments (pharmacological and psychotherapeutic) for SA
This is a 5 years follow-up prospective study recruiting 688 patients. Schedule of the study : Inclusion period : 3 years Duration of follow-up of each patient : 5 years Estimated duration of the study : 8.5 years As part of the research, patients will be summoned annually for 5 years. The first visit (at baseline) is included in the usual care The follow-up visits are specifics to the research During the visits patients will complete self questionary and clinical interview. The organization of visits is as follows: * an inclusion visit lasting around 2 hours (clinical evaluation and then self-questionnaires) * a visit to 1 year, 2 years, 3 years, 4 years and 5 years (+/- 1 month) lasting approximately 1 hour 30 (clinical evaluation and passing of self-questionnaires) Genetic samples will be taken during the initial visit as well as during the visit to 5 years. They consist of: * A genetic collection consisting of a DNA library (3 Ethylene Diamine Triacetic Acid (EDTA) tubes of 6ml - 18 ml). * An off-genetics collection consisting of serum and plasma samples, (1 6 ml EDTA tube, 1 4 ml heparinized tube, 2 dry tubes of 5 ml each and 2 citrated tubes of 2.7 ml each - 25 , 4 ml).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
688
During each visit, a clinical evaluation will be carried out, as well as the filling of hetero-questionnaires and self-questionnaires. Two biological collections will be made: one during the inclusion visit, and the other during the last visit, 5 years after inclusion.
University Hospital of Montpellier
Montpellier, Hérault, France
RECRUITINGLevel of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: At enrollment
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: 1 year after enrollment
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: 2 years after enrollment
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: 3 years after enrollment
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: 4 years after enrollment
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: 5 years after enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: At enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: 1 year after enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: 2 years after enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: 3 years after enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: 4 years after enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: 5 years after enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: At enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: 1 year after enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: 2 years after enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: 3 years after enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: 4 years after enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: 5 years after enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
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Time frame: At enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 1 year after enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 2 years after enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 3 years after enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 4 years after enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 5 years after enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: At enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 1 year after enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 2 years after enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 3 years after enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 4 years after enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 5 years after enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: At enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 1 year after enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 2 years after enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 3 years after enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 4 years after enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 5 years after enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: At enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 1 year after enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 2 years after enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 3 years after enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 4 years after enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 5 years after enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: At enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: 1 year after enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: 2 years after enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: 3 years after enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: 4 years after enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: 5 years after enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: At enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: 1 year after enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: 2 years after enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: 3 years after enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: 4 years after enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: 5 years after enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: At enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: 1 year after enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: 2 years after enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: 3 years after enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: 4 years after enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: 5 years after enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: At enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: 1 year after enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: 2 years after enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: 3 years after enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: 4 years after enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: 5 years after enrollment