Cell Therapy in Critical Limb Ischemia

Inclusion Criteria: 1. The patient is suffering from critical limb ischemia due to atheromatous arteriopathy, and defined as existence of chronic pain at rest or trophic disorders, with a systolic pressure inferior to 50 mm Hg at the ankle or inferior to 30 mm Hg at the toe (respectively 70 and 50 mm Hg in case of trophic disorder), or a transcutaneous measure of oxygen pressure (TcPO2) at the back of the foot in decubitus inferior to 30 mm Hg, and is being subject to a revascularization procedure, associated or not to minimally invasive surgery. Inclusion confirmation will be performed after the revascularization procedure, and treatment planned within 48 hours to 2 weeks after the revascularization procedure. 2. The patient (or his/her legal representative(s)) is capable to understand and comply with study requirements and to provide written informed consent prior to any study procedure for participation in the study and transmission of personal "anonymized" data, which signifies an agreement to enter the study and comply with the restrictions and requirements listed in the informed consent form (ICF). 3. Male or female patients aged ≥18 years at the time of signing the ICF. 4. A female patient is eligible to participate if she is of non-childbearing potential, defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or post-menopausal females defined as 12 months of spontaneous amenorrhea. Females on hormone replacement therapy (HRT) will be required to use one of the treatment methods that does not modify hemostasis parameters (eg chlormadinone acetate \[Lutéran\]) or must discontinue HRT to allow confirmation of post-menopausal status prior to being enrolled in the study. 5. Diabetic patients with an eye fundus examination of less than 3 months excluding proliferative retinopathy 6. Patient with a life expectancy \>12 months Exclusion Criteria: 1. Patients presenting a failure of the revascularization procedure, with technical failure defined as the inability to perform the intended procedure, i.e. * in the case where femoropopliteal bypass was intended, inability to perform the bypass for any reason * in the case where endovascular procedure was intended: * inability to cross the arterial lesion with a guidewire and to catheterize the target vessel * inability to cross the arterial lesion with any endovascular treatment device such as balloons or stents * residual stenosis \> 50% 2. Patient with non atheromatous arteriopathy The patient has, or has a history of, any significant disease or disorder that would increase the risk for the patient if they were enrolled in the study or would affect study procedures or outcomes. 3. The patient is mentally or legally incapacitated. 4. Patient protected by law. 5. Patient who does not benefit from the national health insurance coverage. 6. The patient has been involved in a previous trial with the investigational product. 7. History of cancer excepting basocellular epithelioma during the past 5 years. 8. Patient necessitating chronic hemodialysis or creatinine clearance inferior to 30 mL/min. 9. History of stroke or myocardial infarction of less than 3 months. 10. Hemostasis disorder with contra-indication of intramuscular injections. 11. Patients receiving dual antiplatelet therapy that cannot be temporarily discontinued at least 4 days before and until 6 hours after cell implantation. 12. Patient receiving an antiplatelet therapy with an adenosine diphosphate receptor inhibitor (ADP/P2Y12 inhibitor) that cannot be temporarily discontinued at least 4 days before and until 6 hours after cell implantation. 13. Patient receiving an anticoagulant treatment that cannot be temporarily discontinued until 2 days after the study treatment injection. 14. Patients subject to a below the knee femoro-popliteal bypass procedure or to a femoro-tibial bypass procedure 15. Patients included in another therapeutic trial